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1

New and emerging technologies for genetic toxicity testing

Anthony M. Lynch, Jennifer C. Sasaki, Rosalie Elespuru, David Jacobson-Kram, Véronique Thybaud, Marlies De Boeck, Marilyn J. Aardema, Jiri Aubrecht, R. Daniel Benz, Stephen D. Dertinger, George R. Dou

Journal:

Environmental and Molecular Mutagenesis

Year:

2011

Language:

english

File:

PDF, 350 KB

english, 2011

2

Regulation of genotoxic and carcinogenic impurities in drug substances and products

Timothy McGovern, David Jacobson-Kram

Journal:

TrAC Trends in Analytical Chemistry

Year:

2006

Language:

english

File:

PDF, 91 KB

english, 2006

3

The kinetics of in vivo sister chromatid exchange induction in mouse bone marrow cells by ethylnitrosourea and methylnitrosourea

James L. Charles, David Jacobson-Kram, Lyman W. Condie Jr., Joseph F. Borzelleca, Richard A. Carchman

Journal:

Toxicology and Applied Pharmacology

Year:

1986

Language:

english

File:

PDF, 807 KB

english, 1986

4

Sister-chromatid exchange: second report of the Gene-Tox program

Tucker, James D., Auletta, Angela, Cimino, Michael C., Dearfield, Kerry L., Jacobson-Kram, David, Tice, Raymond R., Carrano, Anthony V.

Journal:

Mutation Research/Reviews in Genetic Toxicology

Year:

1993

Language:

english

File:

PDF, 5.03 MB

english, 1993

5

Evaluation of potential genotoxicity of pulsed electric and electromagnetic fields used for bone growth stimulation

David Jacobson-Kram, John Tepper, Peter Kuo, Richard H.C San, Patrick T Curry, Valentine O Wagner, Donald L Putman

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

1997

Language:

english

File:

PDF, 263 KB

english, 1997

6

Sister-chromatid exchange and cell replication kinetics in fetal and maternal cells after treatment with chemical teratogens

R.K. Sharma, D. Jacobson-Kram, M. Lemmon, J. Bakke, I. Galperin, W.F. Blazak

Journal:

Mutation Research/Genetic Toxicology

Year:

1985

Language:

english

File:

PDF, 962 KB

english, 1985

7

Genetic toxicology assessment of HI-6 dichloride

Donald Putman, Richard H. C. San, C. Anita Bigger, Barry S. Levine, David Jacobson-Kram

Journal:

Environmental and Molecular Mutagenesis

Year:

1996

Language:

english

File:

PDF, 753 KB

english, 1996

8

Analysis for loss of heterozygosity (LOH) of p53 allele in tumors derived from p53+/− and CD-1 mice following repeated subcutaneous injections of solutions containing antioxidants

Ashraf F. Youssef, Flavia Borellini, David Jacobson-Kram, Farrel L. Fort

Journal:

Environmental and Molecular Mutagenesis

Year:

2001

Language:

english

File:

PDF, 60 KB

english, 2001

9

Review of the mutagenicity of ethylene oxide

Vicki L. Dellarco, Walderico M. Generoso, Gary A. Sega, John R. Fowle III, David Jacobson-Kram, H. E. Brockman

Journal:

Environmental and Molecular Mutagenesis

Year:

1990

Language:

english

File:

PDF, 1.87 MB

english, 1990

10

Quantitative estimation of the genetic risk associated with the induction of heritable translocations at low-dose exposure: Ethylene oxide as an example

Lorenz Rhomberg, Vicki L. Dellarco, Cheryl Siegel-Scott, Kerry L. Dearfield, David Jacobson-Kram, H. V. Malling

Journal:

Environmental and Molecular Mutagenesis

Year:

1990

Language:

english

File:

PDF, 1.99 MB

english, 1990

11

Factors influencing mutation at the hprt locus in T-lymphocytes: Studies in normal women and women with benign and malignant breast masses

Dr. Richard F. Branda, J. Patrick O'Neill, David Jacobson-Kram, Richard J. Albertini

Journal:

Environmental and Molecular Mutagenesis

Year:

1992

Language:

english

File:

PDF, 762 KB

english, 1992

12

The kinetics of in vivo sister chromatid exchange induction in mouse bone marrow cells by alkylating agents: Cyclophosphamide

Dr. James L. Charles, David Jacobson-Kram, Joseph F. Borzelleca, Richard A. Carchman

Journal:

Environmental and Molecular Mutagenesis

Year:

1983

Language:

english

File:

PDF, 547 KB

english, 1983

13

The reproductive effects assessment group's report on the mutagenicity of inorganic arsenic

Dr. David Jacobson-Kram, Douglas Montalbano

Journal:

Environmental and Molecular Mutagenesis

Year:

1985

Language:

english

File:

PDF, 1.01 MB

english, 1985

14

The reproductive effects assessment group's review of the mutagenicity of vinylidene chloride

Dr. David Jacobson-Kram

Journal:

Environmental and Molecular Mutagenesis

Year:

1986

Language:

english

File:

PDF, 571 KB

english, 1986

15

Evaluation of the genotoxic potential of zinc pyrithione in the Salmonella mutagenicity (Ames) assay, CHO/HGPRT gene mutation assay and mouse micronucleus assay

N. P. Skoulis, S. J. Barbee, D. Jacobson-Kram, D. L. Putman, R. H. C. San

Journal:

Journal of Applied Toxicology

Year:

1993

Language:

english

File:

PDF, 639 KB

english, 1993

16

The Effects of Diagnostic Ultrasound on Sister Chromatid Exchange Frequencies: A Review of the Recent Literature

Dr. David Jacobson-Kram

Journal:

Journal of Clinical Ultrasound

Year:

1984

Language:

english

File:

PDF, 644 KB

english, 1984

17

Distribution and toxicity resulting from adenoviral vector administration to a single salivary gland in adult rats

Brian C. O'Connell, Changyu Zheng, David Jacobson-Kram, Bruce J. Baum

Journal:

Journal of Oral Pathology & Medicine

Year:

2003

Language:

english

File:

PDF, 140 KB

english, 2003

18

Use of an established human hepatoma cell line with endogenous bioactivation for gene mutation studies

George Chang, David Jacobson-Kram, Jerry R. Williams

Journal:

Cell Biology and Toxicology

Year:

1988

Language:

english

File:

PDF, 761 KB

english, 1988

19

Induction of sister chromatid exchanges by inhibitors of topoisomerases

Meesun Lim, Leroy F. Liu, David Jacobson-Kram, Jerry R. Williams

Journal:

Cell Biology and Toxicology

Year:

1986

Language:

english

File:

PDF, 565 KB

english, 1986

20

Effect of chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on sister chromatid exchange levels in peripheral lymphocytes of the Rhesus monkey

Meesun Lim, David Jacobson-Kram, Robert E. Bowman, Jerry R. Williams

Journal:

Cell Biology and Toxicology

Year:

1987

Language:

english

File:

PDF, 309 KB

english, 1987

21

Comparison of the Ames assay and the induction of sister chromatid exchanges: Results with ten pharmaceuticals and five selected agents

Esmail K. Shubber, David Jacobson-Kram, Jerry R. Williams

Journal:

Cell Biology and Toxicology

Year:

1986

Language:

english

File:

PDF, 1.08 MB

english, 1986

22

Induction of sister chromatid exchanges by benzidine in rat and human hepatoma cell lines and inhibition by indomethacin

Mary Kay Grady, David Jacobson-Kram, Kerry L. Dearfield, Jerry R. Williams

Journal:

Cell Biology and Toxicology

Year:

1986

Language:

english

File:

PDF, 473 KB

english, 1986

23

Pharmacogenomics and regulatory decision making: an international perspective

Mendrick, D L, Brazell, C, Mansfield, E A, Pietrusko, R, Barilero, I, Hackett, J, Stürzebecher, S, Jacobson-Kram, D

Journal:

The Pharmacogenomics Journal

Year:

2006

Language:

english

File:

PDF, 59 KB

english, 2006

24

Activation of polycyclic hydrocarbons in Reuber H4-II-E hepatoma cells an in vitro system for the induction of SCEs

R.G. Dean, G. Bynum, D. Jacobson-Kram, E. Hadley

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1983

Language:

english

File:

PDF, 489 KB

english, 1983

25

Evaluation of a human hepatoma cell line as a target cell in genetic toxicology

Kerry L. Dearfield, David Jacobson-Kram, Nigel A. Brown, Jerry R. Williams

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1983

Language:

english

File:

PDF, 777 KB

english, 1983

26

Ultraviolet-light exposure induces a heritable sensitivity to the induction of SCE by mitomycin-C

John P. Kim, Peter D'Arpa, David Jacobson-Kram, Jerry R. Williams

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1985

Language:

english

File:

PDF, 442 KB

english, 1985

27

DNA topoisomerases and models of sister-chromatid exchange

Larry E. Dillehay, David Jacobson-Kram, Jerry R. Williams

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1989

Language:

english

File:

PDF, 739 KB

english, 1989

28

Evidence for acrolein-modified DNA in peripheral blood leukocytes of cancer patients treated with cyclophosphamide

Melissa A. McDiarmid, P.Thomas Iype, Ken Kolodner, David Jacobson-Kram, Paul T. Strickland

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1991

Language:

english

File:

PDF, 498 KB

english, 1991

29

In vivo ionizing irradiations produce deletions in the hprt gene of human T-lymphocytes

Janice A. Nicklas, J.Patrick O'Neill, Timothy C. Hunter, Michael T. Falta, Malcolm J. Lippert, David Jacobson-Kram, Jerry R. Williams, Richard J. Albertini

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1991

Language:

english

File:

PDF, 876 KB

english, 1991

30

Molecular and genetic toxicology of 1,3-butadiene

David Jacobson-Kram, Sheila L. Rosenthal

Journal:

Mutation Research/Reviews in Genetic Toxicology

Year:

1995

Language:

english

File:

PDF, 833 KB

english, 1995

31

Increased chromosomal radiosensitivity in patients undergoing radioimmunoglobulin therapy

Shuquin Xiao, David Jacobson-Kram, Steven Piantadosi, Jerry R. Williams

Journal:

Mutation Research Letters

Year:

1989

Language:

english

File:

PDF, 475 KB

english, 1989

32

Toxicological overview of impurities in pharmaceutical products

David Jacobson-Kram, Timothy McGovern

Journal:

Advanced Drug Delivery Reviews

Year:

2007

Language:

english

File:

PDF, 121 KB

english, 2007

33

S14: Use of transgenic mice in carcinogenicity hazard assessment: Is this the future?

David Jacobson-Kram

Journal:

Experimental and Toxicologic Pathology

Year:

2009

Language:

english

File:

PDF, 62 KB

english, 2009

34

Editorial introduction

Vicki L. Dellarco, David Jacobson-Kram

Journal:

Mutation Research/Reviews in Genetic Toxicology

Year:

1996

Language:

english

File:

PDF, 94 KB

english, 1996

35

Induction of sister chromatid exchanges in human and rat hepatoma cell lines by cyclophosphamide and phosphoramide mustard and the effects of cytochrome P-450 inhibitors

Kerry L. Dearfield, David Jacobson-Kram, Brian E. Huber, Jerry R. Williams

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 567 KB

english, 1986

36

Methylphenidate and chromosome damage

David Jacobson-Kram, Donald Mattison, Michael Shelby, William Slikker, Raymond Tice, Kristine Witt

Journal:

Year:

2008

Language:

english

File:

PDF, 74 KB

english, 2008

37

Summary of major conclusions from the 4th IWGT, San Francisco, 9–10 September, 2005

D.J. Kirkland, M. Hayashi, D. Jacobson-Kram, P. Kasper, J.T. MacGregor, L. Müller, Y. Uno

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2007

Language:

english

File:

PDF, 113 KB

english, 2007

38

The International Workshops on Genotoxicity Testing (IWGT): History and achievements

D.J. Kirkland, M. Hayashi, D. Jacobson-Kram, P. Kasper, J.T. MacGregor, L. Müller, Y. Uno

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2007

Language:

english

File:

PDF, 100 KB

english, 2007

39

Strategy for genotoxicity testing: Hazard identification and risk assessment in relation to in vitro testing

V. Thybaud, M. Aardema, J. Clements, K. Dearfield, S. Galloway, M. Hayashi, D. Jacobson-Kram, D. Kirkland, J.T. MacGregor, D. Marzin, W. Ohyama, M. Schuler, H. Suzuki, E. Zeiger

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2007

Language:

english

File:

PDF, 738 KB

english, 2007

40

Relevance and follow-up of positive results in in vitro genetic toxicity assays: An ILSI-HESI initiative

Véronique Thybaud, Marilyn Aardema, Daniel Casciano, Vicki Dellarco, Michelle R. Embry, B. Bhaskar Gollapudi, Makoto Hayashi, Michael P. Holsapple, David Jacobson-Kram, Peter Kasper, James T. MacGrego

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2007

Language:

english

File:

PDF, 172 KB

english, 2007

41

Summary of major conclusions from the 5th IWGT, Basel, Switzerland, 17–19 August 2009

D.J. Kirkland, M. Hayashi, D. Jacobson-Kram, P. Kasper, B. Gollapudi, L. Müller, Y. Uno

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2011

Language:

english

File:

PDF, 166 KB

english, 2011

42

Re-evaluation of the mutagenic potential of quinacrine dihydrochloride dihydrate

Jane J Clarke, David C Sokal, Aida M Cancel, Diane B Campen, Ramadevi Gudi, Valentine O Wagner, Richard H.C San, David Jacobson-Kram

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2001

Language:

english

File:

PDF, 177 KB

english, 2001

43

Development of Safety Qualification Thresholds and Their Use in Orally Inhaled and Nasal Drug Product Evaluation

Ball, D., Blanchard, J., Jacobson-Kram, D., McClellan, R. O, McGovern, T., Norwood, D. L, Vogel, W., Wolff, R., Nagao, L.

Journal:

Toxicological Sciences

Year:

2007

Language:

english

File:

PDF, 228 KB

english, 2007

44

In vitro assays of in vivo exposure to cyclophosphamide: Induction of sister-chromatid exchanges in peripheral lymphocytes, bone-marrow cells and in cultured cells exposed to plasma

Kerry L Dearfield, David Jacobson-Kram, Susan K Buenaventura, Jerry R Williams

Journal:

Mutation Research/Genetic Toxicology

Year:

1985

Language:

english

File:

PDF, 631 KB

english, 1985

45

Baseline and phosphoramide mustard-induced sister-chromatid exchanges in cancer patients treated with cyclophosphamide

Melissa A. McDiarmid, Paul T. Strickland, Ken Kolodner, John Hansen, David Jacobson-Kram

Journal:

Mutation Research/Genetic Toxicology

Year:

1990

Language:

english

File:

PDF, 447 KB

english, 1990

46

Baseline and phosphoramide mustard-induced sister-chromatid exchanges in pharmacists handling anti-cancer drugs

Melissa A. McDiarmid, Ken Kolodner, Frances Humphrey, Donald Putman, David Jacobson-Kram

Journal:

Mutation Research/Genetic Toxicology

Year:

1992

Language:

english

File:

PDF, 757 KB

english, 1992

47

Polycyclic Aromatic Hydrocarbon Biomarkers of Internal Exposure in U.S. Army Soldiers Serving in Kuwait in 1991

Poirier, Miriam C., Weston, Ainsley, Schoket, Bernadette, Shamkhani, Hanadi, Pan, Ching-fei, Mc diarmid, Melissa A., Scott, Brian G., Deeter, David P., Heller, Jack M., Jacobson-kram, David, Rothman,

Journal:

Polycyclic Aromatic Compounds

Year:

1999

Language:

english

File:

PDF, 474 KB

english, 1999

48

Diagnostic ultrasound and sister chromatid exchanges: failure to reproduce positive findings

Ciaravino, V, Brulfert, A, Miller, M., Jacobson-Kram, D, Morgan, W.

Journal:

Year:

1985

Language:

english

File:

PDF, 736 KB

english, 1985

49

Supplement 3: Environmental Mutagenesis in Human Populations at Risk || Measurement of Chromosomal Aberrations, Sister Chromatid Exchange, hprt Mutations, and DNA Adducts in Peripheral Lymphocytes of Human Populations at Increased Risk for Cancer

David Jacobson-Kram, Richard J. Albertini, Richard F. Branda, Michael T. Falta, P. Thomas Iype, Ken Kolodner, Saou-Hsing Liou, Melissa A. McDiarmid, Marcia Morris, Janice A. Nicklas, J. Patrick O'Neil

Journal:

Environmental Health Perspectives

Year:

1993

Language:

english

File:

PDF, 943 KB

english, 1993

50

Heritable Hypersensitivity to Induced Mutagenesis in the Progeny of Cell Populations Exposed to UVC (254 nm)

Peter D'Arpa, Larry E. Dillehay, John W. Opishinski, David Jacobson-Kram and Jerry R. Williams

Journal:

Radiation Research

Year:

1989

Language:

english

File:

PDF, 688 KB

english, 1989